MPL e MBL

Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancer.

QUESTIONS UNDER STUDY Mannan-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are two key components of the lectin-pathway of complement-activation. Information on the potential role of lectin-pathway components in carcinogenesis versus immune surveillance of cancer is scarce. This study aimed to determine if serum concentrations of MBL and MASP-2 differ between children with ...

Bacteria despite MBL Binding Opsonophagocytosis of Yeasts but Not of Mannose-Binding Lectin (MBL) Facilitates

Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl(-/-) mice: a new system for Mpl structure-function studies.

Mpl is the thrombopoietin (TPO) receptor. The current molecular understanding of how Mpl activation stimulates proliferation of megakaryocyte-lineage cells is based largely on the engineered expression of Mpl in nonmegakaryocyte-lineage cell lines. However, the relevance of these findings to Mpl signaling in primary megakaryocyte-lineage cells remains largely unknown. Therefore, a system was de...

Infusion of plasma-derived mannan-binding lectin (MBL) into MBL-deficient humans.

Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MBL. Some years later, we treated a young girl with recurrent, debilitating infe...

Mpl and thrombocytosis: levels matter.

P ronounced thrombocytosis can result from decreased expression of the thrombopoietin (Tpo) receptor, Mpl, in late megakaryocytes and platelets. In this issue of Blood, Lannutti and colleagues1 and Tiedt and colleagues2 generate transgenic mice expressing Mpl and use these models to investigate the relationships between Mpl, expression and platelet production. In these mouse models, a 2 kb prox...